Louisiana’s first-in-the-nation law listing the abortion medications mifepristone and misoprostol as “controlled dangerous substances” took effect Tuesday, triggering fears among health-care providers and pharmacists that routine care may be worsened for women in the state.

Starting Tuesday in Louisiana, mifepristone and misoprostol will be reclassified as controlled substances in the state, making it a crime punishable by up to five years in prison to possess the drugs without a prescription.

On Tuesday, Louisiana will become the first state in the U.S. to categorize two widely used abortion pills as “controlled dangerous substances.”