Joe Mixon has missed the Texans past two games with an ankle injury, but he could make his return in Week 5.

The Houston Texans will be without star running back Joe Mixon for their matchup against the Jacksonville Jaguars. Mixon has been dealing with an ankle injury that he suffered during Week 2 against the Chicago Bears.

Mixon was ruled out for Sunday’s game against the Jacksonville Jaguars due to a sprained ankle suffered against the Chicago Bears in a game-time decision after returning to practice Friday morning, per league sources. There is optimism that he could return to play this week against the Buffalo Bills.